Effects of Prunella vulgaris L. on Expressions of IL-1α,IL-4,IL-8 and TNF-α in Saliva of Patients with Acne

Abstract

Abstract: Objective To detect effects of Prunella vulgaris L. on expressions of IL-1α、IL-4、IL-8 and TNF-α in saliva of patients with acne. Methods 100 patients with severe acne were treated with water extract of Prunella vulgaris L. for a week, 15 g·d-1 each person, including 38Ⅱlevel patients, 27 Ⅲ level patients, 35 Ⅳ level patients. 40 cases of normal people were selected as control. The levels of IL-1α, IL-4, IL-8 and TNF-α were respectively measured before and after treatment by ELISA kits. Results Compared with the control group, the levels of IL-1α, IL-4, IL-8 and TNF-α had different degree of rise. The variability of the population were all Ⅳ level＞Ⅲ level＞Ⅱ level. The levels of IL-1α, IL-4, IL-8 and TNF-α were significantly decreased. Conclusion The onset of acne was closely related with the expression of IL-1α, IL-4, IL-8 and TNF-α in saliva, illustrating the immune factors played important roles in the onset and development of acne. Further study of the pathogenesis of acne immune mechanism has a guiding significance for clinical diagnosis and therapy, Prunella vulgaris L. may be effective for acne by adjusting peripheral immune factors in patlents with acne.

Key words: Prunella vulgaris L., acne, saliva, IL-1α, IL-4, IL-8, TNF-α

CLC Number:

R965
R282

ZHAO Jun-ru,WANG Wen-yu,ZUO Fu-guo,LI Xiao-qian,HU Dong-pei. Effects of Prunella vulgaris L. on Expressions of IL-1α,IL-4,IL-8 and TNF-α in Saliva of Patients with Acne[J]. Chinese Journal of Pharmacovigilance, 2015, 12(3): 140-143.

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