Abstract: Objective To study one case of ischemic colitis (IC) caused by compound polyethylene glycol electrolyte powder so as to provide a reference for safe medication. Methods The process of diagnosis and treatment of one case of IC that occurred after compound polyethylene glycol electrolyte powder was used for bowel preparation was analyzed. Based on related literature, drugs that might have induced IC in this patient were identified before the possible mechanisms and treatments were explored. Results The adverse reaction of the patient was diagnosed as IC. After such factors as the patient’s underlying diseases, concomitant medications, and colonoscopy were excluded, the correlations between compound polyethylene glycol electrolyte powder and IC were considered “probable”. After symptomatic treatment, the patient gradually improved. Conclusion IC is a rare adverse reaction caused by polyethylene glycol electrolyte solution. When early symptoms of IC are found in patients, the chances of IC induced by polyethylene glycol electrolyte solution should be considered and therapeutic interventions implemented quickly.

Key words: Polyethylene Glycol Electrolyte, Bowel Preparation, Ischemic Colitis, Colonoscopy, Adverse Drug Reaction