Analysis of 501 Cases of Drug-induced Kidney Injury

Abstract

Abstract: Objective To analyze the regular pattern and characteristics of drug-induced kidney injury and provide reference for the use of clinical drug. Methods 501 drug-induced kidney injury cases from 2009 to 2014 were collected from the database of PLA ADR monitoring center. Age and gender of patients, categories of suspected drugs, route of administration, occurrence time, clinical feature and prognosis were statistically analyzed. Results The 501 cases were composed of 175 female patients (34.93%) and 326 male patients (65.07%). The average age of the patients was (53.48±21.99) years. The adverse drug reactions were caused by 197 kinds of drugs, among which the anti-infective drugs ranked first, with 221 related cases. Intravenous infusion was the primary administration route and the occurrence time of ADRs was mainly within one week. Most cases had good prognosis, with 356 cases (71.06%) cured or improved. Conclusion A wide category of drugs may cause drug-induced kidney injury. Therefore, much more attention should be paid on the high-risk drugs and high-risk groups.

Key words: drug-induced kidney injury, adverse drug reaction, statistical analysis

CLC Number:

R994.11

ZHAO Liang, GUO Dai-hong*, ZhU Man, XU Yuan-jie, MA Liang, ZHAO Peng-zhi, CAI Le, ZHAO Su-yu, WANG Zhong-qiang. Analysis of 501 Cases of Drug-induced Kidney Injury[J]. Chinese Journal of Pharmacovigilance, 2015, 12(10): 627-631.

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