Analysis of 76 Reports of Adverse Drug Reaction Induced by Cefoperazone/Tazobactam

Abstract

Abstract: Objective To summarize the characteristics and rules of adverse drug reactions (ADRs) induced by cefoperazone/tazobactam and provide prevention countermeasures for clinical safe, effective and rational use of antimicrobials by analysis of antibacterial-related ADR reports. Methods 76 ADR reports were statistically analyzed from Jan, 2005 to May, 2015 in our hospital to ADR monitoring center. The patient's age, gender, diseases, usage and dosage, ADR occurrence time and clinical manifestations were analyzed retrospectively. Results Among the 76 cases of ADR, the difference in gender aspect was not significant (P ＞0.05). There were statistically significant differences of the age, kinds of diseases(P ＜0.01). Less than 30 minutes after administration were ADR high-incidence period (59.21%). The main side effects were injuries of skin and its appendages (55.22%), and followed by systemic damage and hematological system damage, etc. 76 cases of ADR including 7 reports of serious adverse reactions, allergic shock and hematological system were involved in the most of cases. Conclusion The indication and dosage of cefoperazone/tazobactam should be strictly mastered by clinicians, and the pharmaceutical care of cefoperazone/tazobactam should be strengthened. The medical staff should tell patients potential ADR and prepare the emergency treatment measures for incidentally critical ADR.

Key words: cefoperazone/tazobactam, adverse drug reactions, rational drug use

CLC Number:

ZHONG Xun-long, FENG Xia, DUAN Lian, YE Li-ka, WANG Ruo-lun. Analysis of 76 Reports of Adverse Drug Reaction Induced by Cefoperazone/Tazobactam [J]. Chinese Journal of Pharmacovigilance, 2015, 12(10): 623-626.

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