Effects of Radix Polygoni Multiflori Preparata and Quantitative Exercise on Rat Liver Microcirculation and Liver Function

Abstract

Abstract: ObjectiveTo investigate the long-term effects of taking Radix Polygoni multiflori Preparata combined quantitative exercise on hepatic microcirculation and liver function. Methods2×2 factor experimental design was used. Rats were randomly divided into four groups, namely, static without drug group(S/C), static with drug group (S/D), swim without drug group(SW/C), swim with drug group(SW/D), given the different levels of Radix Polygoni multiflori Preparata alcohol extract (0g·kg-1, 20g·kg-1 p.o) and different levels of swimming(0h, 1h). After 30 days, using Laser Doppler blood flow imaging system to monitor the change of rat hepatic microcirculation blood flow; the serums of rats were collected to determine the content of NOS3 and the biochemical indexes of liver function. ResultsCompared with S/C group, Radix Polygoni multiflori Preparata alcohol extract significantly reduced the mean perfusion unit of hepatic microcirculation and serum endothelial nitric oxide synthase(NOS3) content(P <0.05) in rats, while significantly elevated serum total bilirubin(TBIL), direct bilirubin(DBIL), reduced indirect bilirubin(IBIL)

CLC Number:

R965

CHANG Qing, ZHAO Hai-juan, LI Chun, LIAO Fu-long, WANG Jia-bo, XIAO Xiao-he, YOU Yun. Effects of Radix Polygoni Multiflori Preparata and Quantitative Exercise on Rat Liver Microcirculation and Liver Function[J]. Chinese Journal of Pharmacovigilance, 2014, 11(4): 193-197.

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