Abstract: ObjectiveIn order to standardize preventive use of antibacterials during perioperative period in our hospital, a control study was conducted to compare the preventive use of antibacterials in aseptic operation before-and-after interventions. MethodsAccording to retrospective method, 300 cases were randomly selected from the first quanter of 2010, the first quanter of 2011 and the first quanter of 2012, respectively. The preventive use of antibacterials in aseptic operation was analyzed and evaluated. ResultsAfter the intervention, the proportion of cases using antibacterial was obviously reduced, the antibacterial cost was decreased significantly, the rationality of antibacterial use was obviously enhanced. ConclusionThe comprehensive intervention measures to optimize the preventive use of antibacterials during perioperative period in our hospital are effective and feasible.

Key words: comprehensive intervention, aseptic operation, preventive use of antibacterials, perioperative period