Abstract: Objective To compare the conventional medication education with strengthened medication education on survival, rehospitalization and reoperation rate of coronary heart disease patients. Methods We collected and analyzed 165 cases of hospitalized patients from January 1,2012 to May 31,2012, whose first diagnosis was CHD, coronary angiography showed stenosis <60%, never implanted any stents. They were divided into control group and intensive education group. Followed up patient survival, readmission and reoperation rate after 12 months, analyzed differences between two groups. Results Compared with the conventional, intensive education group readmission and reoperation rates were significantly reduced, but no significant difference in survival. Conclusion The strengthened medication education can significantly reduce readmission rates in patients with coronary heart disease and improve their quality of life and prolong life expectancy.