Abstract: ObjectiveTo investigate whether ademetionine 1,4-butanedisulfonate and cefoperazone/sulbactam is imcompatible, and research how the white floccule emerged. MethodsBy controlled trial, apperance change was observed after combining each medicine with acid solution and alkaline solution, and apperance change was observed after combining the mixed liquid of two medicines with acid solution and alkaline solution. ResultsNo evident apperance change was observed by normal dispensing. cefoperazone/sulbactam solution immediately generated white precipitate after adding acid solution, and the white precipitate could be dissolved in alkaline solution. ConclusionThere was no precipitate after mixing the two medicines by normal dispensing, the reason of white precipitate was to dissolve transmetil incorrectly. The two medicines may be compatible by correct dispensing.

Key words: ademetionine 1, 4-butanedisulfonate, cefoperazone/sulbactam, imcompatibility