Abstract: Objective To investigate the characteristics and regularities of anaphylactic shock induced by ceftriaxone sodium and provide the clinical reference of the drug safety. MethodsData were collected from domestic published literatures between 2001 to 2010 and 97 case reports of anaphylactic shock induced by Ceftriaxone Sodium were analyzed retrospectively.Results87.6% of anaphylactic shock occurred in the first time use of Ceftriaxone Sodium and 67.1% of the reaction happened within 10 minutes of drug administration.The mortality rate of anaphylactic shock by Ceftriaxone Sodium were 18.6%. Clinical overuse and irrational combination of Ceftriaxone Sodium were found. ConclusionRational use of Ceftriaxone Sodium is important. Close observation of drug reaction and well preparation for anaphylactic shock are recommended.

Key words: ceftriaxone sodium, adverse drug reaction, anaphylactic shock