Abstract: Objective To evaluate efficacy and safety of Xueshuantong for acute brain infraction, from which to provide scientific proofs for clinical decision making. Methods We firstly retrieved and selected publications and then we assessed methodological quality of the included articles. Afterwards, employing Cochrane Collaboration's software RevMan 5.0, we conducted Meta-analyses with fixed or random effect models. Results A total of 11 papers were included in the study and the methodological quality was graded to C. As for total response rate, RRs and 95%CI were 1.33(1.10~1.44), 1.32(1.20~1.45), 1.37(1.22~1.53) and there were statistical differences between Xueshuantong alone and other Traditional Chinese Medicines(TCMs) alone, Xueshuantong+other drugs and TCMs+other drugs, Xueshuantong+other drugs and other TCMs alone. The sensitivity analysis tested and verified the reliability of the results above where P values were less than 0.001. Conclusion The adoption of Xueshuantong for acute brain infraction can improve total response rate as compared with other included Traditional Chinese drug interventions. However, because of low quality and relatively small sample size of the included studies, further multicenter randomized controlled trials with large sample size should be conducted to investigate the effectiveness and safety of Xueshuantong for acute brain infraction.

Key words: Xueshuantong, efficacy, safety, Meta-analysis, acute brain infraction