Abstract: Objective To know the progress in the methods for determination of Synephrine and to provide the basis for its quality evaluation and its safe use. Methods Look up related professional literatures and summarize the progress. Results The methods for determination of Synephrine are various, including HPLC, RP-HPLC, TLC,CE, pSFC and others. Conclusion The methods of determination are developing continuously. We must choose reliable methods and strictly control the content of Synephrine to ensure its safe and effective use.

Key words: Synephrine, determination method, research progress, safe and effective