Chinese Journal of Pharmacovigilance ›› 2011, Vol. 8 ›› Issue (8): 459-461.

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Study on Mechanism of Cytokine and NO Injury in the Hepatotoxical Injury in Rats Caused by Volatile Oil from Bupleurum Chinense

YANG Qian1, 2, SUN Rong1, *   

  1. 1 Shandong Academy of Chinese Medicine, Shandong Jinan 250014;
    2 Shandong University of Traditional Chinese Medicine, Shandong Jinan 250355
  • Received:2011-04-20 Online:2011-08-10 Published:2015-07-30

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Abstract: Objective To study the effects of cytokine and NO on the hepatotoxical injury caused by volatile oil from Bupleurum Chinense and offer experimental basement for the explanation of mechanisms of hepatotoxical injury. Methods Volatile oil from Bupleurum Chinense of different dosages was given to Wistar rats by intragastric administration for fifteen days consecutively. The activity of iNOS and contents of TNF-α,IL-6,IL-10 and NO both in serum and liver were tested after the last administration. Results The siginificant increase of activity of iNOS and contents of TNF-α,IL-6,IL-10 and NO both in serum and liver can be induced by volatile oil from Bupleurum Chinense. Conclusion Hepatotoxical injury caused by volatile oil from Bupleurum Chinense can be mediated via cytokine. Nitric can aggravate the injury but the path by which it reacted is left to be studied.

Key words: volatile oil from Bupleurum Chinense, hepatotoxicity, cytokine, nitrogen monoxidum

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