Abstract: Objective To summarize and analyze acute severe anaphylactoid reaction cases of nonionic coronary contrast media during coronary angiography and/or percutaneous coronary intervention. Methods We retrospectively evaluated the outcomes of 24 314 patients undergoing coronary angiography and/or percutaneons coronary inter-vention in our hospital from December 2007 to December 2009, and analyzed the cases with acute severe anaphylactoid reactions to nonionic contrast media． Results 9 patients exhibited severe anaphylactoid reactions to nonionic contrast media, which typically occured within 1 hour after intravascular injection.The incidence is about 0.037%.The main symptom of severe anaphylactoid reactions to nonionic contrast media was significantly lower blood pressure, with various degree of arrhythmia, accompanied by symptoms of other systems. Oxygen, rehydration, and application of high-dose boost drugs(especially epinephrine) and corticosteroids were effective Methods of treatment. Conclusion Nonionic contrast media can be used safely during coronary angiography and/or percutaneous coronary intervention. However, in the application process, identification and treatment for acute severe anaphylactoid reactions should be strengthened.

Key words: nonionic coronary contrast media, acute severe anaphylactoid reaction, analysis