Abstract: Objective To investigate the epidemiology of adverse drug reaction(ADR) of β-lactams antibiotics and its preventive measure. Methods We classified and analyzed 249 cases of adverse drug reaction of β-lactams antibiotics which is reported to National center for ADR Monitoring during 2006～2009, according to the type of adverse drug reaction、pharmacological action, age, sex, form of medication. Results adverse drug reaction of β-lactams involved in skin and its appendix、central nervous system、digestion system、hematological system、urinary system and so on. Among them skin and its appendix、central nervous system and gastrointestinal reactions are easy to acquire, others are obscure and difficult to find. Conclusion To comprehend the past hypersensitive history before administration, decrease drug combination, select rational administration, and administrate according to instruction dosage is the fundamental path to prevent ADR.

Key words: β-lactams antibiotics, adverse drug reaction, rational administration