One Case of Tuberculosis Caused by Infliximab and Ustekinumab

doi:10.19803/j.1672-8629.20250104

Abstract

Abstract: Objective To investigate such adverse reactions as tuberculosis (TB) reactivation induced by infliximab and ustekinumab, and to explore the underlying mechanism. Methods One case of TB reactivation induced by infliximab and ustekinumab in a patient with Crohn’s disease was analyzed and related literature was reviewed. Results This patient with Crohn’s disease received long-term infliximab therapy. Treatment was discontinued due to the development of TB. After anti-TB treatment, ustekinumab was initiated. However, TB reoccurred after two courses of treatment. The patient then received prophylactic anti-tuberculosis therapy with isoniazid and rifampin concurrently with the re-initiation of ustekinumab. Results showed that the PPD test turned negative, and that TB symptoms occurred no more. Conclusion Infliximab and ustekinumab are commonly used biological agents for Crohn’s disease. While these drugs are immunosuppressive, they can cause infectious adverse reactions. Although ustekinumab is considered a relatively safe immunomodulator, it can still induce TB. Clinicians are advised to monitor patients for TB adverse reactions when infliximab or Ustekinumab is used. For patients who receive chronic ustekinumab therapy, prophylactic anti-TB treatment should be administered.

Key words: Crohn’s Disease, Tuberculosis, Infliximab, Ustekinumab, Adverse Drug Reaction

CLC Number:

ZHOU Wei, WANG Liyuan, WANG Fang, SUN Yanyan, XIA Yimiao, WANG Facai. One Case of Tuberculosis Caused by Infliximab and Ustekinumab[J]. Chinese Journal of Pharmacovigilance, 2026, 23(1): 105-108.

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https://zgywjj.magtechjournal.com/EN/Y2026/V23/I1/105

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