Adverse Reactions to Antihypertensive and Hypoglycaemic Drugs Based on Spontaneous Presentation Systems

doi:10.19803/j.1672-8629.20240675

Abstract

Abstract: Objective To analyze the reports of adverse drug reactions(ADR) caused by antihypertensive and hypoglycemic drugs so as to provide a reference for rational clinical use of drugs. Methods The ADR reports related to commonly-used antihypertensive and hypoglycemic drugs collected by the Guangdong ADR self-reporting system between September 1, 2020 and August 31, 2022 were analyzed, and the influential factors for the occurrence of severe ADR were identified. Results A total of 6 113 ADR reports involving 9 207 clinical cases were included. Females and middle-aged and elderly patients accounted for a large proportion. Mild ADR and severe ones accounted for 90.22% and 9.78% respectively. In addition, there were 844 new ADR (13.81%). ADR mostly involved the gastrointestinal system and the skin and its accessories or were systemic, with calcium channel blocker drugs and biguanides as the leading cause. ADR caused by different drugs varied. Most of these ADR occurred 2 to 7 days (29.45%) and 30 days (40.95%) after medication, and the majority of the patients improved (58.23%) or recovered (35.25%). Patients with two or more types of primary diseases, smoking history, and ADR induction time of over 7 days were at higher risk of severe ADR. Conclusion The ADR caused by commonly-used drugs for diabetes and hypertension vary, depending on age, gender, organs involved and types of drugs. It is recommended that clinicians take precautions, monitor and assess patients at critical time points after medication in order to detect potential ADR quickly to keep patients safe.

Key words: Hypertension, Diabetes, Anti-Hypertensive Drugs, Hypoglycemic Drugs, Adverse Drug Reaction, Gastrointestinal System

CLC Number:

LIAO Mengfan, ZHONG Liling, XU Yan, LIU Ying, ZHANG Yexiang, CHEN Qingsong, LIU Xudong. Adverse Reactions to Antihypertensive and Hypoglycaemic Drugs Based on Spontaneous Presentation Systems[J]. Chinese Journal of Pharmacovigilance, 2025, 22(3): 286-291.

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