Abstract: Objective To validify the evidence of adriamycin cardiotoxicity via animal experiments based on the analysis of TCM medications used for the prevention and treatment of adriamycin cardiotoxicity in order to provide data for related treatment. Methods Literature related to the prevention and treatment of anthracycline cardiotoxicity with TCM and published between the inception to March 1st, 2024 was searched for from some databases to analyze the pattern of medications and to establish a rat model of anthracycline cardiotoxicity via injection with doxorubicin at 3.5 mg•kg-1. Results A total of 104 Chinese herbal medicines, such as Astragalus, Glycyrrhiza glabra, Maitong, Ginseng, Radix et Rhizoma Ginseng, Radix et Rhizoma Ginseng, and Salviae Miltiorrhizae, were included. The efficacy of these drugs was determined as tonifying deficiency, activating blood circulation, removing blood stasis, clearing heat, eliminating phlegm, and expelling dampness. Anthracycline cardiotoxic rats showed dirty fur, hair loss, loose stools, stasis of blood, depression, lethargy, decrease in anal temperatures, and dark tongue color. The serum contents of antidiuretic hormone, aldosterone, and antithrombin Ⅲ were significantly decreased while the content of D-dimer was significantly increased. Conclusion The development of drugs for prevention and treatment of anthracycline cardiotoxicity should involve tonifying the deficiency, stimulating blood circulation, eliminating stasis, expelling dampness and resolving turbidity.

Key words: adriamycin, cardiotoxicity, medication pattern, evidence, pharmacovigilance