Abstract: Objective To find out about the establishment and applications of animal models for drug-induced cardiotoxicity, and to provide data for the prevention and treatment of drug-induced cardiotoxicity. Methods Literature research was conducted using “cardiotoxicity” as the key term. Related literature on applications of drug-induced cardiotoxicity models published since 2015 was selected from the CNKI and Web of Science Core Collection databases. Literature about experimental research on applications of animal models for drug-induced cardiotoxicity was screened based on the inclusion criteria. Analysis software Citespace 6.3 R1 (64-bit) Basic as well as Excel was used to visualize the selected literature. Results A total of 731 articles were included. The model animals used in studies of drug-induced cardiotoxicity were mostly rats, mice and zebrafish while the modeling agents were chiefly adriamycin, aconitine and bupivacaine. The toxicity mechanism involved oxidative stress and apoptosis. Most studies used such multi-category indicators as general indicators, histopathological indicators, and cardiac function test indicators for comprehensive evaluation. The applications were also relatively concentrated, and there were great differences in the criteria for evaluating drug-induced cardiotoxicity models. Conclusion Research on drug-induced cardiotoxicity models remains promising, which can facilitate systematic development of Traditional Chinese Medicine for the prevention and treatment of drug-induced cardiotoxicity.

Key words: drug-induced, cardiotoxicity, animal model, evaluation indicators, pharmacovigilance, rat, mice, zebrafish