Research Progress in Chemical Constituents, Pharmacology and Toxicology of Volatile Oil in Asarum

doi:10.19803/j.1672-8629.2021.04.21

Abstract

Abstract: The clinical application of Asarum in traditional Chinese medicine is very extensive. Volatile oil, as a main active ingredient of Asarum, has a series of pharmacological effects such as anesthesia, antipyretic action, analgesia, anti-inflammation. However, Asarum volatile oil is also generally considered the material basis of its toxic and side effects, and improper use may lead to serious toxic reactions. In this study, the main components of Asarum volatile oil and recent research on their pharmacological and toxicological effects were categorized, analyzed and summarized by reviewing literature published over the past ten years. There is the need to carry out targeted pharmacodynamic and toxicological research on the main components of Asarum volatile oil in order to provide reference for the rational and effective application of Asarum and ensure the safety of clinical medication.

Key words: Asarum, volatile oil, chemical composition, pharmacological action, toxicological effects

CLC Number:

R285

QIAN Shensi, LIU Meiyi, RONG Rong, YANG Yong. Research Progress in Chemical Constituents, Pharmacology and Toxicology of Volatile Oil in Asarum[J]. Chinese Journal of Pharmacovigilance, 2021, 18(4): 388-395.

References

[1] Wang B, Jiang B, Shen XK, et al.Analysis of volatiles from asarum heterotropoides by gas chromatography-mass spectroscopy[J]. Chinese Archives of Traditional Chinese Medicine(中华中医药学刊), 2014, 32(11): 2726-2729.
[2] Zhao J, Ni MP, Jing SJ, et al.Study on compositions from Asarum volatile oil by ionic liquid-based headspace microextraction GC-MS[J]. Lishizhen Medicine and Materia Medica Research(时珍国医国药), 2015, 26(2): 296-298.
[3] Wang BB, Qi W, Wang LL, et al.Comparative study of chemical composition, antinociceptive effect and acute toxicity of the essential oils of three Asarum drugs[J]. Journal of Chinese Pharmaceutical Sciences, 2014, 23(7): 480-489.
[4] Li JH, Yan W, Cui EJ, et al.GC-MS analysis of volatile oil components of asarum from different habitats[J]. Lishizhen Medicine and Materia Medica Research(时珍国医国药), 2019, 30(1): 188-190.
[5] Wang GJ, Qi ML.Analysis of volatile compounds in Herba Asari by single-drop micro-extraction gas chromatography mass spectrometry[J]. Chinese Chemical Letters, 2013, 24(6): 542-544.
[6] Chellian R, Pandy V.Protective effect of α-asarone against nicotine-induced seizures in mice, but not by its interaction with nicotinic acetylcholine receptors[J]. Biomedicine & Pharmacotherapy, 2018, 108: 1591-1595.
[7] Yuan SY, Wang XH, Sun JY, et al.Influences of α-asarone on the expression of P-glycoprotein and multidrug resistance genes in brain tissues of drug-resistant epileptic model rats[J]. Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease(中西医结合心脑血管病杂志), 2019, 17(21): 3322-3325.
[8] Wang WX.The influence of methyleugenol on anti-epilepsy and discharge of hippocampal neuron of, asarum in rats[D]. Shandong University of Traditional Chinese Medicine, 2017.
[9] Figuêiredo F, Monteiro B, Menezes IRAD, et al.Effects of the hyptis martiusii benth. leaf essential oil and 1,8-cineole (eucalyptol) on the central nervous system of mice[J]. Food and Chemical Toxicology, 2019, 133:110802.
[10] Wang ZJ, Tabakoff B, Levinson SR, et al.Inhibition of Nav1.7 channels by methyl eugenol as a mechanism underlying its antinociceptive and anesthetic actions[J]. Acta Pharmacologica Sinica, 2015, 36(7): 791-799.
[11] Wen P, Li LL, Niu YF, et al.Preliminary study on radix et rhizoma asari intervention in mice depression[J]. World Chinese Medicine(世界中医药), 2018, 13(4): 794-798.
[12] Park HJ, Lim EJ, Zhao RJ, et al.Effect of the fragrance inhalation of essential oil from Asarum heterotropoides on depression-like behaviors in mice[J]. BMC Complementary and Alternative Medicine, 2015, 15(1): 43.
[13] Liu JX, Wang D, Liu S, et al.Research progress of the effects and mechanisms of alpha-asarone and beta-asarone in cardio-cereb-rovascular diseases[J].Progress in Modern Biomedicine(现代生物医学进展), 2019, 19(9): 1797-1800.
[14] Zhang Y, Song ZY, Wang LL.Pharmacological action and clinical application of asarum[J]. China Pharmaceuticals(中国药业), 2007, 16(14): 62-63.
[15] Yang H, Xu F, Wan D, et al.Study of antinociceptive and anti-inflammatory effect and antinociceptive mechanism of methyleugenol[J]. Traditional Chinese Drug Research and Clinical Pharmacology(中药新药与临床药理), 2017, 28(3): 292-297.
[16] Bó WD, Luiz AP, Martins DF, et al.Eugenol reduces acute pain in mice by modulating the glutamatergic and tumor necrosis factor alpha (TNF-α) pathways[J]. Fundamental & Clinical Pharmacology, 2013, 27(5): 517-525.
[17] Gui YL, Li AY, Zhang J, et al.α-Asarone alleviated chronic constriction injury-induced neuropathic pain through inhibition of spinal Endoplasmic reticulum stress in a liver X receptor-dependent manner[J]. Anesthesia and Analgesia, 2018, 127(3): 775-783.
[18] Liu J, Liu GX, Shang MY, et al.Identification based on HPLC and anti-inflammatory targets as well as related constituents analysis of Asarum heterotropoides var. mandshuricum and A. sieboldii[J]. China Journal of Chinese Materia Medica(中国中药杂志), 2020, 45(6): 1374-1383.
[19] Deng PH, Huang CJ, Zhao FZ, et al.Expression of TGF-β1 and VEGF and intervention effect of asarone in asthmatic mice[J]. Journal of New Medicine(新医学), 2018, 49(1): 25-29.
[20] Shao LJ, Tang F.Mechanism research on the effects of mahuang and xixin on allergic rhinitis in rats[J]. Information on Traditional Chinese Medicine(中医药信息), 2019, 36(5): 47-49.
[21] Wu N, Zhang XL, Hou Y, et al.Effect of methyl eugenol on nasal mucosal aquaporin 5 in rats with allergic rhinitis[J]. Journal of Peking University Health Sciences, 2019, 51(6): 1036-1041.
[22] Lim HJ, Wan WK, Lee KR, et al.Inhibition of proinflammatory cytokine generation in lung inflammation by the leaves of perilla frutescens and its constituents[J]. Biomolecules & Therapeutics, 2014, 22(1): 62-67.
[23] Zhang L, Yu B, Yang B, et al.Antirejection effect of herba asari extract in rats after cardiac allograft implantation[J]. Transplantation Proceedings, 2009, 41(10): 4328-4331.
[24] Wang BY, Zhang FF, Han QQ, et al.Effect of α-Asarone on esophageal eca-109 cell mitochondrial apoptosis pathway[J]. Herald of Medicine(医药导报), 2018, 37(1): 27-30.
[25] Feng YK, Wang H, Wang Q, et al.Chemical interaction of protein cysteine residues with reactive metabolites of methyleugenol[J]. Chemical Research in Toxicology, 2017, 30(2): 564-573.
[26] Yu Q, Chen YH, Ju H, et al.Molecular docking of volatile oily constituents of chinese herbal medicine asari radix et rhizoma and CYP1A2 enzyme[J]. Chinese Journal of Experimental Traditional Medical Formulae(中国实验方剂学杂志), 2020, 26(9): 202-207.
[27] Li YM, Han LT, Huang CH, et al.New contributions to asarum powder on immunology related toxicity effects in lungs[J]. Evidence-based Complementary and Alternative Medicine : eCAM, 2018, 2018:1054032.
[28] Wang YK, Yang XN, Zhu X, et al.Role of metabolic activation in elemicin-induced cellular toxicity[J]. Journal of Agricultural and Food Chemistry, 2019, 67(29): 8243-8252.
[29] Janardhan KS, Rebolloso Y, Hurlburt G, et al.Histopathological and immunohistochemical characterization of methyl eugenol-induced nonneoplastic and neoplastic neuroendocrine cell lesions in glandular stomach of rats[J]. Toxicologic Pathology, 2015, 43(5): 681-693.
[30] Zhang ML, Lin N, Deng Q, et al.Research progress on preclinical toxicity of asarone[J]. Journal of Toxicology(毒理学杂志), 2019, 33(2): 161-165.
[31] Chinese Pharmacopoeia Commission.Pharmacopoeia of the people's Repuhlic of China (part 1)[中华人民共和国药典(一部)] [M]. Beijing: China Medical Suience Press, 2000: 185
[32] Chinese Pharmacopoeia Commission.Pharmacopoeia of the people's Repuhlic of China (part 1)[中华人民共和国药典(一部)] [M]. Beijing: China Medical Suience Press, 2005: 185