Analysis of One Case of Liver Injury Induced by Levetiracetam Oral Liquid

doi:10.19803/j.1672-8629.2020.12.21

Abstract

Abstract: Objective To remind the medical staff to pay close attention to medication safety of levetiracetam.Methods An epileptic pediatric patient who developed a significant elevation of the liver enzymes during levetiracetam monotherapy was reported while literature about the relativity and pathogenesis of levetiracetam-induced liver injury was consulted.Results The liver enzymes were surprisingly decreased to normal after levetiracetam discontinuation in this patient. The Roussel Uclaf causality assessment method score was 6, indicating levetiracetam was a probable cause for the liver damaged.Conclusion The levetiracetam-associated potential liver enzymes elevation should be considered when levetiracetam is prescribed to patients, especially pediatric patients, close liver function monitoring was necessary..

Key words: levetiracetam, drug-induced liver injury, antiepileptic drugs, hepatotoxicity

CLC Number:

R994.11

YANG Bei, FANG Yuting. Analysis of One Case of Liver Injury Induced by Levetiracetam Oral Liquid[J]. Chinese Journal of Pharmacovigilance, 2020, 17(12): 943-945.

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https://www.zgywjj.com/EN/Y2020/V17/I12/943

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