Abstract: Objective To analyze the incidence,dominating types and related factors of adverse drug reaction (ADR) in patients at an epilepsy physician-pharmacist joint clinic and to provide evidence for individualized treatment of epilepsy. Methods A retrospective survey was conducted among patients who visited the epilepsy physician-pharmacist joint clinic in our hospital in 2020-2021. The gender and age of these patients and incidence of adverse reactions were statistically analyzed before Chi-square tests were performed on the correlations between the incidence of ADR and gender, age and combined medications. Results The incidence of ADR averaged 36.17% (251/694), which was 37.08% among male patients (142/383) and 35.05% among female ones (109/311), so the difference was of no statistical difference (χ ²=0.306, P=0.580). The incidence of ADR was 24.00%, 33.88%, 42.96%, and 55.10% respectively in the group aged 14 or older, in the group ages 15 to 44, in the group aged 45-64 and in the group aged 65 and older, so the difference was statistically significant (χ ²=16.226, P=0.001). The incidence of ADR in patients treated with combinations of drugs and those without was 45.00% and 26.65%, respectively, and the difference was of statistical significance (χ ²=25.279, P=0.000). Conclusion Medications for epilepsy should be individualized based on the gender, age, and combination of drugs. Patients or their family members should be reminded of the importance of regular re-examination to ensure the safety of medication.

Key words: epilepsy, physician, pharmacist, joint clinic, antiepileptic drugs, adverse drug reactions, individualized treatment