中国药物警戒 ›› 2024, Vol. 21 ›› Issue (12): 1405-1410.
DOI: 10.19803/j.1672-8629.20240636

• 中药治疗脑卒中研究进展专栏 • 上一篇    下一篇

中药复方治疗出血性脑卒中研究进展

刘柘君1,2, 唐田3, 谭天阳4, 白雪1,*   

  1. 1中国中医科学院医学实验中心, 北京市中医药防治重大疾病基础研究重点实验室,北京 100700;
    2首都医科大学中医药学院,北京 100026;
    3中国科学院北京基因组研究所,北京 100101;
    4中国中医科学院西苑医院,北京 100091
  • 收稿日期:2024-08-23 出版日期:2024-12-15 发布日期:2024-12-16
  • 通讯作者: *白雪,女,博士,助理研究员,中药防治脑血管疾病。E-mail: dr.baixue@hotmail.com
  • 作者简介:刘柘君,女,在读博士,中药防治脑血管疾病。
  • 基金资助:
    中国中医科学院西苑医院院级师承项目（YJMPS- C202437）; 国家自然科学基金资助项目（82304767）; 中央级公益性科研院所基本科研业务费专项基金（JJPY2022021、ZZ15-YQ-055）; 中国中医科学院科技创新工程项目（CI2021B017）

Research Progress on Traditional Chinese Medicine Compound Formulae against Hemorrhagic Stroke

LIU Zhejun1,2, TANG Tian3, TAN Tianyang4, BAI Xue1,*   

  1. 1Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment of Major Disease, Beijing 100700, China;
    2School of Traditional Chinese Medicine, Capital Medical University, Beijing 100026, China;
    3Chinese Academy of Sciences (CAS) Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China;
    4Xiyuan Hospital, Chinese Academy of Traditional Chinese Medicine, Beijing 100091, China
  • Received:2024-08-23 Online:2024-12-15 Published:2024-12-16

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摘要： 目的 探究近年来中药复方治疗出血性脑卒中的临床疗效和作用机制,进一步挖掘中药复方更多潜在应用价值。方法 检索中国知网数据库从建库至2024年8月中药复方治疗脑卒中相关文献,梳理、归纳和总结中药复方治疗出血性脑卒中的研究进展。结果 临床研究表明,益髓破血方、活血化瘀中药汤剂等中药复方可改善患者神经功能,减轻脑水肿,促进康复,提高生活质量。其机制研究揭示,中药复方可能通过多靶点、多途径作用,发挥包括保护神经元、改善脑血管通透性、改善微循环、减少炎症反应、减轻氧化应激、抑制细胞凋亡、焦亡和铁死亡等药理学作用。结论 中药复方有望在出血性脑卒中的综合治疗中发挥更大作用,为患者提供更加个体化、精准化的治疗选择,但目前研究多为小样本观察性研究,证据级别有限。未来需要开展更多高质量的临床研究,进一步验证中药复方治疗出血性脑卒中的疗效。

关键词: 中药复方, 出血性脑卒中, 神经, 临床疗效, 作用机制, 益髓破血方, 活血化瘀中药汤剂

Abstract: Objective To explore the research progress in clinical efficacy and mechanisms of action of traditional Chinese medicine compound formulae in the treatment of hemorrhagic stroke in recent years, and to find out more about the potential applications of traditional Chinese medicine compound formulae. Methods Literature related to TCM compound formulae against hemorrhagic stroke that was published from inception to August 2024 was searched for in National Knowledge Infrastructure (CNKI) databases, while related research progress was summarized. Results Clinical studies showed that such TCM compound formulae as Yisui Poxue formula and decoctions for invigorating blood and removing blood stasis could do much to improve the neurological function of patients, reduce cerebral edema, facilitate recovery and improve the quality of life. Studies on the mechanisms suggested that TCM compound formulae could exert such pharmacological effects as protection of neurons, improvement of microcirculation, reduction of inflammatory response, attenuation of oxidative stress, inhibition of apoptosis, pyroptosis and ferroptosis in multi-target and multi-pathway ways. Conclusion With in-depth research, TCM compound formulae are expected to play a greater role in the comprehensive treatment of hemorrhagic stroke and provide patients with more individualized and precise treatment options, but most of the current studies are small-sample observational studies with limited evidence. More high-quality clinical studies are needed in the future to validate the efficacy of TCM compound formulae in the treatment of hemorrhagic stroke.

Key words: Traditional Chinese Medicine Compound Formulae, Hemorrhagic Stroke, Neurons, Clinical Efficacy, Mechanism, Yisui Poxue Formula, Decoctions for Invigorating Blood and Removing

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