基于传统文献的围孕期妇女中药药物警戒挖掘与药学服务思考

doi:10.19803/j.1672-8629.2022.06.01

摘要/Abstract

摘要： 目的挖掘围孕期妇女临床应用中药的药物警戒思想,为临床药学服务与安全合理用药提供依据。方法梳理唐至清代20部妇（产）科专著,提取有关围孕期妇女临床用药的警戒表述,包括围孕期阶段、疾病、药物、禁忌、使用注意等警戒内容。采用对比分析、归纳总结等,形成围孕期妇女用药警戒。结果依据备孕、妊娠、临产、产时、产褥和哺乳等阶段,分别形成辨证/症/病论“忌”、因人制“忌”、因时制“忌”、剂量与疗程控制、药食禁忌等警戒措施,指导临床合理用药。并针对围孕期妇女不同阶段特点,分别从药物、机体、用药等方面开展药学服务。结论围孕期妇女各阶段的药物警戒措施侧重不同,临床须充分考虑生理及病理特点,开展药学服务与合理用药指导。

关键词: 围孕期妇女, 备孕, 妊娠, 临产, 产后, 中药, 药物警戒, 药学服务

Abstract: Objective To explore ancient theories about pharmacovigilance for progestational, pregnant and post-partum women in Chinese medicine, and provide reference for clinical pharmaceutical care and safe use of Chinese medicine. Methods Statements about pharmacovigilance were collected from 20 books on gynaecology and obstetrics published from the Tang Dynasty to the Qing Dynasty. Such information as phases, diseases, drugs, contraindications and precautions was retrieved. Notions of pharmacovigilance in Chinese medicine were ultimately collected via comparisons and summaries. Results In such phases as pregnancy preparation, pregnancy, perinatal and post-partum periods, pharmacovigilance measures for Chinese medicine included contraindications based on syndromes/ symptoms/ diseases, those based on people and time, control of dosage and courses of treatment, and dietary incompatibility. Such factors as drugs, patients and medications should be taken into consideration in pharmaceutical care according to the characteristics of different phases. Conclusion Pharmacovigilance measures for progestational, pregnant and post-partum women vary. Pharmaceutical care and guidance for rational use of Chinese medicine should be delivered based on physiological and pathological characteristics.

Key words: progestational, pregnant and post-partum women, pregnancy preparation, pregnancy, perinatal, post-partum, traditional Chinese medicine, pharmacovigilance, pharmaceutical care

中图分类号:

吕锦涛, 张晓朦, 张冰, 姜皓, 林志健. 基于传统文献的围孕期妇女中药药物警戒挖掘与药学服务思考[J]. 中国药物警戒, 2022, 19(6): 585-590.

LYU Jintao, ZHANG Xiaomeng, ZHANG Bing, JIANG Hao, LIN Zhijian. Chinese medicine pharmacovigilance and pharmaceutical care for progestational, pregnant and post-partum women based on ancient literature[J]. Chinese Journal of Pharmacovigilance, 2022, 19(6): 585-590.

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