复方妥英麻黄茶碱片致苯妥英钠中毒1例分析

doi:10.19803/j.1672-8629.20240626

中国药物警戒 ›› 2025, Vol. 22 ›› Issue (7): 819-822.
DOI: 10.19803/j.1672-8629.20240626

复方妥英麻黄茶碱片致苯妥英钠中毒1例分析

雷建林, 王娜, 王文筝, 王岩^*

西安交通大学第二附属医院药学部,陕西西安 710004

收稿日期:2024-09-04 出版日期:2025-07-15 发布日期:2025-07-17
通讯作者: ^*王岩,男,博士,研究员,抗菌药物个体化用药研究。E-mail:Wangyan0819@mail.xjtu.edu.cn
作者简介:雷建林,女,硕士,副主任药师,药物警戒与治疗药物监测研究。

One Case of Phenytoin Intoxication Caused by Compound Phenytoin Sodium Ephedrine Hydrochloride and Theophylline Tablets

LEI Jianlin, WANG Na, WANG Wenzheng, WANG Yan^*

Department of Pharmacy, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an Shaanxi 710004, China

Received:2024-09-04 Online:2025-07-15 Published:2025-07-17

摘要/Abstract

摘要： 目的探讨1例哮喘患者服用复方妥英麻黄茶碱片（CPEHTT）致苯妥英钠中毒案例的临床特征及中毒机制,警示其用药风险,为临床合理用药提供参考。方法分析1例哮喘患者服用CPEHTT致头晕及共济失调病例,检索PubMed、Web of Science、Ovid、中国知网,CPEHTT引起苯妥英钠中毒相关报道,并对不良反应发生机制进行讨论。结果根据治疗药物监测结果、不良反应关联性评价、诺氏量表评分,考虑CPEHTT致苯妥英钠中毒,经停药并对症治疗,患者症状好转并治愈。结论 CPEHTT可能存在苯妥英钠中毒风险,用药需谨慎。

关键词: 复方妥英麻黄茶碱片, 苯妥英钠, 中毒, 药品不良反应, 药物警戒

Abstract: Objective To provide a reference for pharmacovigilance by analyzing the clinical characteristics and mechanisms of phenytoin sodium poisoning induced by compound phenytoin sodium, ephedrine hydrochloride and theophylline tablets (CPEHTTs) in an asthmatic patient. Methods One case of dizziness and ataxia induced by CPEHTTs in a patient with asthma was analyzed. Case reports of phenytoin sodium poisoning caused by CPEHTTs were retrieved from PubMed, Web of Science, Ovid and CNKI Full-text databases. The mechanism of adverse drug reactions (ADR) was explored. Results According to the correlation evaluation of ADR, the score of the Naranjo's scale and the Results of therapeutic drug monitoring, CPEHTTs were considered to have caused phenytoin sodium poisoning. After discontinuation of the drug and initiation of symptomatic treatment, the patient’s symptoms gradually subsided and recovered. Conclusion CPEHTT may carry the risk of phenytoin sodium poisoning, so they should be used with caution.

Key words: Compound Phenytoin Sodium Ephedrine Hydrochloride and Theophylline Tablets, Phenytoin Sodium, Drug Poisoning, Adverse Drug Reactions, Pharmacovigilance

中图分类号:

R974

雷建林, 王娜, 王文筝, 王岩. 复方妥英麻黄茶碱片致苯妥英钠中毒1例分析[J]. 中国药物警戒, 2025, 22(7): 819-822.

LEI Jianlin, WANG Na, WANG Wenzheng, WANG Yan. One Case of Phenytoin Intoxication Caused by Compound Phenytoin Sodium Ephedrine Hydrochloride and Theophylline Tablets[J]. Chinese Journal of Pharmacovigilance, 2025, 22(7): 819-822.

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复方妥英麻黄茶碱片致苯妥英钠中毒1例分析

One Case of Phenytoin Intoxication Caused by Compound Phenytoin Sodium Ephedrine Hydrochloride and Theophylline Tablets

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