Abstract: Objective To review the research status of Senecio scandens clinical adverse reactions, in order to offer accordance and study ideas for further safety evaluation. Methods References in the last decades at home and abroad about Senecio scandens clinical reports of adverse reactions were collated, analyzed and summarized. Results The most serious adverse reaction of Senecio scandens is hepatotoxicity, which is related to the long-term use, dosage, a mixture of varieties, compatibility, preparation technology and the difference of individual, and especially long-term use is the main cause of death of clinical cases. Studies have shown that pyrrolizidine alkaloids (PAs) contained in Senecio scandens are the main material basis of hepatotoxicity. Conclusion For the causes of Senecio scandens clinical adverse reactions, the hepatotoxicity damage regularity and material basis of Senecio scandens and its Chinese traditional patent medicine should be urgently studied, and intracorporal process of toxic substances and "toxicodynamics-toxicokinetics" relevance evaluation are distinguished, to formulate safety margin of the body, perfect and improve the quality standards as well as ensure clinical medication safety.

Key words: Senecio scandens, adverse reactions, causes