LC-MSn Analysis of the Components in Bulbus Fritillariae Ussuriensis and the Urine of Rats after Oral Administered Bulbus Fritillariae Ussuriensis

Chinese Journal of Pharmacovigilance ›› 2014, Vol. 11 ›› Issue (4): 203-205.

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LC-MSn Analysis of the Components in Bulbus Fritillariae Ussuriensis and the Urine of Rats after Oral Administered Bulbus Fritillariae Ussuriensis

ZHANG Li-fu^{1, 2}, SUN Jian², WEN Qinghui³, MA Yanyan², Feng-Lan Niu^{1, *}

Abstract: Objective To investigate the components in Bulbus Fritillariae ussuriensis by LC-MSn, and to quickly identify components in rats urine after orally administered Bulbus Fritillariae ussuriensis. Methods The structures of components in Bulbus Fritillariae ussuriensis were detected by LC-MSn experiments, combined with the same kind of compound standard of mass spectrometry cracking rule, identification of each chromatographic peak, then identify the urine within the same way. Results 11 components were identified from Bulbus Fritillariae ussuriensis, and 8 components were identified from the urine of rats after orally administered Bulbus Fritillariae ussuriensis. Conclusion This method can be used for accurate identification of steroidal alkaloid components in Bulbus Fritillariae ussuriensis and the urine of rats after orally administered Bulbus Fritillariae ussuriensis.

Received:2014-01-15 Revised:2016-02-03 Online:2014-04-08 Published:2016-02-03

Abstract

CLC Number:

R965

ZHANG Li-fu, SUN Jian, WEN Qinghui, MA Yanyan, Feng-Lan Niu. LC-MSn Analysis of the Components in Bulbus Fritillariae Ussuriensis and the Urine of Rats after Oral Administered Bulbus Fritillariae Ussuriensis[J]. Chinese Journal of Pharmacovigilance, 2014, 11(4): 203-205.

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LC-MSn Analysis of the Components in Bulbus Fritillariae Ussuriensis and the Urine of Rats after Oral Administered Bulbus Fritillariae Ussuriensis

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