Abstract: ObjectiveTo explore the use of cluster analysis method in adverse drug reaction monitoring. MethodsIn order to define the characteristics of different manufacturers, the manufacturers were grouped by the cluster analysis method based on the clindamycin hydrochloride injection adverse reaction monitoring data which were in the charge of 9 manufacturers(coded as A to I). ResultsThe 9 manufacturers were classified as 4 groups according to the system-organ that adverse drug reactions attacked. There was great difference between the groups. The adverse reactions of certain drug had different characteristics in different group of manufacturers. ConclusionDifferent manufacturers' production process may lead to different adverse drug reactions. Cluster analysis method can be used in the adverse drug reaction monitoring.

Key words: adverse drug reaction, monitoring, cluster analysis, exploration