Chinese Journal of Pharmacovigilance ›› 2012, Vol. 9 ›› Issue (5): 275-278.

• Orginal Article • Previous Articles     Next Articles

The Effeet of Extracting Methods on "Quality Toxicity" Comprehensive Evaluation Model of Rhizome et Rhizome Sophorae Tonkinensis

ZHENG Li-na1,2, SUN Rong2*   

  1. 1 Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;
    2 Shandong Academy of Chinese Medicine, Shandong Jinan 250014, China
  • Received:2012-03-29 Online:2012-05-10 Published:2015-08-10

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Abstract: Objective Explore the effeet of extracting methods on "quality-toxicity" comprehensive evaluation model by comparing the content of alkaloid and acute toxicity from Radix et Rhizome Sophorae Tonkinensis extracted by different methods. the quality control methodology of alkaloid substance from Radix et Rhizome Sophorae Tonkinensis was studied. MethodsHPLC was used to determine the content of matrine and oxymatrine in water extract and alcohol extract of Radix et Rhizome Sophorae Tonkinensis. ResultsIn the determination of matrine and oxymatrine in different components of Radix et Rhizome Sophorae Tonkinensis, it was found that the size order of the content of matrine is water extract>alcohol extract, and the content of oxymatrine is alcohol extract>water extract. ConclusionThere is a certain relationship between the content of matrine and oxymatrine and acute toxicity in different components of Radix et Rhizome Sophorae Tonkinensis, but not completely consistent. There was certain effeet of extracting methods on "quality toxicity" comprehensive evaluation model. It was more comprehensive, Objective and reasonable to determine extraction methods of toxic Chinese medicine through the comprehensive evaluation model.

Key words: Rhizome et Rhizome Sophorae Tonkinensis, matrine, oxymatrine, acute toxicity