Research Progress in Correlations between SGLT2 Inhibitors and Malignant Tumors

doi:10.19803/j.1672-8629.20250082

Abstract

Abstract: Objective To explore the correlations between SGLT2i as a new anti-tumor drug for regulating glucose uptake and malignant tumors in order to provide data for tumor research. Methods The latest research findings on the mechanism of SGLT2i in lung cancer, breast cancer, thyroid cancer, colorectal cancer and liver cancer were reviewed. Results SGLT2i could significantly reduce the all-cause mortality of NSCLC patients, effectively inhibit the growth of MCF-7 cells of breast cancer, promote apoptosis of thyroid cancer and colorectal cancer cells, and drastically reduce the risk of non-alcoholic fatty liver disease and liver cancer. Conclusion The combination of SGLT2i as a potential anti-cancer therapy with current standard chemotherapy may offer a new line of thought for research. However, the expressions and specific mechanism of action of SGLT2i in different cancers, the activity of drugs of different subtypes and the efficacy and safety of the combination of drugs require more experimental evidence.

Key words: SGLT2i, Lung Cancer, Breast Cancer, Thyroid Cancer, Colorectal Cancer, Liver Cancer, Malignant Tumor, Mechanism

CLC Number:

R979.1

GAO Caiyun, WANG Boyuan, GAO Xiaojie. Research Progress in Correlations between SGLT2 Inhibitors and Malignant Tumors[J]. Chinese Journal of Pharmacovigilance, 2025, 22(7): 836-840.

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