Abstract: Objective To explore how clinical pharmacists can give pharmaceutical care by recommending cardiotoxic chemotherapy drugs for patients with coronary heart disease after gastric cancer surgery. Methods By analyzing and comparing the cardiotoxicity of conventional chemotherapy drugs after gastric cancer surgery, a proper treatment for the patient was selected. Results Fluorouracil is the basic drug used for postoperative adjuvant chemotherapy for gastric cancer. It was replaced by raltitrexed with less cardiotoxicity, which was combined with oxaliplatin as a chemotherapy regimen. Conclusion The selection of chemotherapy drugs should be based on assessment of the risk of cardiotoxicity among patients with heart-based diseases.

Key words: gastric cancer, chemotherapy, coronary heart disease, rectal cancer, pharmaceutical care