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15 December 2019, Volume 16 Issue 12 Previous Issue    Next Issue

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Effects of Emodin-8-O-β-D-glucopyranoside on Tumor Cell Migration and Metastasis in Vitro and in Vivo LI Yiqun, LIANG Huanxi, LIU Changzhen, SUN Zhenxiao 2019, 16(12): 705-710.  DOI: 10.19803/j.1672-8629.2019.12.01 Abstract ( 832 )   PDF (4954KB) ( 233 )   Objective To investigate the effects of emodin-8-O-β-D-glucopyranoside (EG) on tumor cell migration in vitro and tumor metastasis of tumor-bearing mice in vivo. Methods Different kinds of cells (mouse breast cancer cell 4T1-Luc, human colorectal cancer cell HCT116 and human neuroblastoma cell SH-SY5Y) were treated with 0, 100, 200, 400 mg·mL-1 EG while cell proliferation, cell migration and metastasis ability were detected by MTT assay, wound healing and Transwell assay respectively. Then, orthotopic 4T1-Luc bearing mice were treated with phosphate-buffer saline (PBS) and EG at low (2 mg·kg-1) and high (4 mg·kg-1) doses for 13 days respectively. Tumor metastasis was observed by the animal imaging system every two days during the period. Results EG could inhibit tumor cell migration in a concentration- and time-dependent manner in these three kinds of cells. It also inhibited tumor cell metastasis in a concentration-dependent manner. In the animal study, EG could also inhibit tumor metastasis in 4T1-Luc bearing mice. Conclusion EG has the ability to inhibit tumor cell migration and metastasis both in vitro and in vivo. References | Related Articles | Metrics

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Development and Safety Monitoring of Electronic Data Capture System for Vaccine Clinical Trials LIANG Xinyuan, MO Yi, FENG Shuo, YANG Huan, MO Zhaojun 2019, 16(12): 711-715.  DOI: 10.19803/j.1672-8629.2019.12.02 Abstract ( 677 )   PDF (4799KB) ( 195 )   Objective To solve the existing problems with traditional paper-based data collection, such as poor security and liability, slow data aggregation and high cost, and to explore the application of the Electronic Data Capture (EDC) System and data safety monitoring. Methods An Electronic Data Capture (EDC) System was designed that was specifically used for vaccine clinical trials based on Chinese standards and requirements. With an integrated hardware and software solution, the man-machine system was able to collect and process data according to certain application Objectives and rules. Each of the functional modules was verified in a comprehensive, rigorous and standard way on one of the clinical trial sites in Guangxi. Results The system proved to be capable of recording and storing information, querying and verifying data, statistical analysis and data-derivation, which could ensure vaccine safety monitoring and data collection by means of online real-time monitoring of the subjects’ follow-up visit status and adverse events. Conclusion This EDC system can not only meet the needs of Chinese vaccine clinical trials and the second development, but provide a platform in support of large sample clinical trial monitoring and management as well as safety monitoring, thus layinga solid foundation for establishing systematic vaccine-drug pharmacovigilance systems. References | Related Articles | Metrics

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An Overview of EU SPOR Project HOU Yongfang, LIU Hongliang, LI Xinling, LIU Ling 2019, 16(12): 716-721.  DOI: 10.19803/j.1672-8629.2019.12.03 Abstract ( 779 )   PDF (5274KB) ( 307 )   Objective To study the details of implementation of EMA SPOR Program so as to offer ideas and referential methodologies for IDMP-related practices in China. Methods IDMP standards as well as the EMA SPOR Program were studied by analyzing the ways in which a drug dictionary was compiled by the EU that complies with the IDMP standards. A comparison was also made with the actual situation in China. Results IDMP standards involve an enormous data structure, and the SPOR Program effectively divides the whole process into reasonable and executable phases, allowing smooth communication and collaboration between stakeholders across phases. Conclusion The implementation of the SPOR Program will be of multiple benefits: increased data quality, more efficient regulatory action and decision-making, reduced data silos and operational savings and efficiencies due to re-usage of data. References | Related Articles | Metrics

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Current Construction of Monitoring and Evaluation System of Adverse Drug Reactions in Anhui Province HONG Wei, WANG Feng 2019, 16(12): 722-726.  DOI: 10.19803/j.1672-8629.2019.12.04 Abstract ( 837 )   PDF (4472KB) ( 353 )   Objective To investigate the status quo of the construction of ADR monitoring and evaluation systems at the grass-roots level, analyze the main problems, and explore the countermeasures. Methods Questionnaires were used to investigate the construction of ADR monitoring organization, staffing, monitoring personnel and monitoring networks in Anhui Province. Results In Anhui Province, only provincial centers and four cities had independent monitoring agencies, while twelve cities and one hundred and five counties (districts) did not. Part-time monitors in monitoring institutions of cities, counties (districts) and health care professionals accounted for 70.3% and 46.9% respectively. Conclusion The grass-roots ADR monitoring institutions and personnel cannot meet the needs of ADR monitoring under new circumstances. It is urgent to strengthen the construction of ADR monitoring and evaluation systems at grass-roots levels. References | Related Articles | Metrics

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Meta-analysis of Efficacy and Safety of Edaravone for Amyotrophic Lateral Sclerosis WEI Hongtao, LI Dandan, WU Tingxi, CHENG Sheng 2019, 16(12): 727-733.  DOI: 10.19803/j.1672-8629.2019.12.05 Abstract ( 568 )   PDF (4554KB) ( 194 )   Objective To explore the efficacy and safety of edaravone used among patients with amyotrophic lateral sclerosis (ALS). Methods PubMed, Cochrane library, CNKI and Wanfang electronic databases were searched manually. Randomized controlled trials which involved edaravone in the treatment of ALS and published between January 1994 and December 2017 were collected. Citations were extracted according to the predefined inclusion criteria, and the quality of included studies was assessed based on the Cochrane Collaboration’s tool for assessing the risk of bias. RevMan 5.3 software was used for statistical analysis. Results A total of five studies (609 cases) were included. Meta-analysis showed that edaravone significantly improved the revised ALS functional rating score (SMD=0.80, 95%CI: 0.62~0.98, P < 0.00001), but did not reduce mortality (RR=0.73, 95%CI: 0.36~1.46, P =0.37) compared with the control group. The incidence of adverse events in the edaravone group was not significantly different from that of the control group (RR=0.91, 95%CI: 0.70~1.19, P =0.10). Conclusion Edaravone has good safety profiles. Despite its inabiity to reduce the mortality of ALS, it can ameliorate the function of ALS patients. References | Related Articles | Metrics

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Analysis of the use of Esazolam Tablets in 10 Hospitals in Yunnan Province BAI Liqin, WANG Jun 2019, 16(12): 734-740.  DOI: 10.19803/j.1672-8629.2019.12.06 Abstract ( 779 )   PDF (4391KB) ( 300 )   Objective To promote the standardized and rational use of psychotropic drugs, reduce the medication risks of psychotropic drugs, and explore the feasibility and methods of drug abuse monitoring in medical institutions by analyzing the use of estazolam tablets in 10 hospitals in Yunnan province. Methods The prescription of estazolam tablets in hospital was analyzed retrospectively. Results 68 559 prescriptions of psychotropic drugs were collected, of which 28, 386 (41.04%) were estazolam tablets; the average age of patients taking estazolam tablets was 58.82±17.01 years old, the maximum was 101 years old and the minimum was 3 years old. There were overindications and overdosage prescriptions. Conclusion Hospitals should prescribe reasonably and guide patients to use estazolam tablets correctly to reduce irrational medication and prevent drug dependence. References | Related Articles | Metrics

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Analysis of 40 Cases of Adverse Reactions to Apatinib Mesylate ZHANG Xialan, SHEN Xikun, WU Bin 2019, 16(12): 741-746.  DOI: 10.19803/j.1672-8629.2019.12.07 Abstract ( 679 )   PDF (4432KB) ( 257 )   Objective To summarize the characteristics of adverse drug reactions caused by apatinib mesylate and provide data for safe and rational medication. Methods The gender, age, clinical diagnosis, history of adverse reactions, dosage, frequency of administration, organs or systems involved, clinical manifestations, time of occurrence, treatment and prognosis of adverse reactions were statistically analyzed among 40 patients with apatinib-caused adverse reactions. Results Elder males were more vulnerable to adverse reactions caused by apatinib. The main symptoms of adverse reactions included elevated blood pressure, gastrointestinal reactions, fatigue, abnormal liver function and skin lesion. There were 22 cases of mild adverse reactions and 18 cases of serious adverse reactions. Conclusion Adverse drug reactions caused by apatinib should be more effectively monitored to improve the safety of medication. References | Related Articles | Metrics

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Pharmaceutical Care for One Case of Coronary Heart Disease Accompanied by Postoperative Gastric Cancer WANG Mingyue, WU Wei, YUE Feng, YI Zhaoguo, XU Jing 2019, 16(12): 747-749.  DOI: 10.19803/j.1672-8629.2019.12.08 Abstract ( 408 )   PDF (3072KB) ( 111 )   Objective To explore how clinical pharmacists can give pharmaceutical care by recommending cardiotoxic chemotherapy drugs for patients with coronary heart disease after gastric cancer surgery. Methods By analyzing and comparing the cardiotoxicity of conventional chemotherapy drugs after gastric cancer surgery, a proper treatment for the patient was selected. Results Fluorouracil is the basic drug used for postoperative adjuvant chemotherapy for gastric cancer. It was replaced by raltitrexed with less cardiotoxicity, which was combined with oxaliplatin as a chemotherapy regimen. Conclusion The selection of chemotherapy drugs should be based on assessment of the risk of cardiotoxicity among patients with heart-based diseases. References | Related Articles | Metrics

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Recent Research Progress in Mechanism of Liver Injury Induced by Common Drugs LI Hongying, YANG Cuiping, JIN Hongtao 2019, 16(12): 750-756.  DOI: 10.19803/j.1672-8629.2019.12.09 Abstract ( 831 )   PDF (6293KB) ( 402 )   Objective To summarize the latest research progress related to drug-induced liver injury in order to achieve a better understanding of the related mechanisms. Methods Through literature search and summary, the mechanisms of drug actions which are likely to induce liver injury were summarized, involving non-steroidal anti-inflammatory drugs, antibiotics and antifungal drugs, nervous system drugs, and Chinese herbal medicines. Results The mechanisms of liver injury by these drugs are related to mitochondrial dysfunction and oxidative stress, gene polymorphism, active metabolites and immune response. Conclusion More studies on the mechanisms of drug-induced liver injury are required to reduce the occurrence of drug-induced liver injury and guide the rational use of related drugs. References | Related Articles | Metrics

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One Case of Liver Injury Induced by Bosentan Tablets PAN Manmang, LIU Xiaoyan, ZUO Xiaocong, ZHOU Lingyun, GU Zhi chun 2019, 16(12): 757-758.  DOI: 10.19803/j.1672-8629.2019.12.10 Abstract ( 562 )   PDF (1989KB) ( 238 )   References | Related Articles | Metrics

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One Case of Anaphylactic Shock with Hemolytic Anemia Induced by Cedodizime Sodium for Injection HONG Qian 2019, 16(12): 759-761.  DOI: 10.19803/j.1672-8629.2019.12.11 Abstract ( 511 )   PDF (2736KB) ( 256 )   References | Related Articles | Metrics

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One Case of Hepatic Dysfunction Induced by Olaparib Tablets XU Yinying, JIANG Sunmin 2019, 16(12): 762-764.  DOI: 10.19803/j.1672-8629.2019.12.12 Abstract ( 567 )   PDF (2487KB) ( 219 )   References | Related Articles | Metrics

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One Case of Tinnitus and Hearing Loss Induced by Moxifloxacin Hydrochloride QU Gguanghong, LI Jinfeng, LI Fengjun, ZHANG Yuan 2019, 16(12): 765-766.  DOI: 10.19803/j.1672-8629.2019.12.13 Abstract ( 811 )   PDF (1923KB) ( 250 )   References | Related Articles | Metrics

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One Case of Dyspnea and Skin Rash Induced by Parecoxib Sodium for Injection ZHANG Yan, WANGJiajia, WANGXiaolei 2019, 16(12): 767-768.  DOI: 10.19803/j.1672-8629.2019.12.14 Abstract ( 542 )   PDF (1742KB) ( 205 )   References | Related Articles | Metrics