Recent Research Progress in Mechanism of Liver Injury Induced by Common Drugs

doi:10.19803/j.1672-8629.2019.12.09

Abstract

Abstract: Objective To summarize the latest research progress related to drug-induced liver injury in order to achieve a better understanding of the related mechanisms. Methods Through literature search and summary, the mechanisms of drug actions which are likely to induce liver injury were summarized, involving non-steroidal anti-inflammatory drugs, antibiotics and antifungal drugs, nervous system drugs, and Chinese herbal medicines. Results The mechanisms of liver injury by these drugs are related to mitochondrial dysfunction and oxidative stress, gene polymorphism, active metabolites and immune response. Conclusion More studies on the mechanisms of drug-induced liver injury are required to reduce the occurrence of drug-induced liver injury and guide the rational use of related drugs.

Key words: drug-induced liver injury, mechanism, hepatotoxicity

CLC Number:

R994.11

LI Hongying, YANG Cuiping, JIN Hongtao. Recent Research Progress in Mechanism of Liver Injury Induced by Common Drugs[J]. Chinese Journal of Pharmacovigilance, 2019, 16(12): 750-756.

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