Literature Analysis of 126 Cases of Adverse Drug Reactions Induced by Oxaliplatin

Abstract

Abstract: Objective To investigate the laws and characteristics of adverse drug reactions (ADRs) induced by oxaliplatin, and to provide references for the clinical rational use of drugs. Methods To retrieve the related literature of the adverse reactions induced by oxaliplatin in CNKI from January, 2000 to May, 2018, and to analyze the 126 cases collected from the samples of literature. Results The main adverse reactions induced by oxaliplatin involved neurotoxicity and anaphylaxis, as well as blood toxicity, nephrotoxicity and cardiac toxicity, which caused much damage on the multiple systems, mainly including respiratory system, whole system, central and peripheral nervous system, with the complex and diverse clinical features. The adverse reactions were more likely to occur within 30 minutes after medication, in which more than 85% occur within 6 hours, and the ratio in women was slightly higher than in men. Conclusion Supervision and precaution should be strengthened in the clinical use of oxaliplatin.

Key words: oxaliplatin, adverse drug reactions, literature

CLC Number:

R994.11

WANG Hui, XU Li, ZHAO Li, XU Wei, WANG Beili. Literature Analysis of 126 Cases of Adverse Drug Reactions Induced by Oxaliplatin[J]. Chinese Journal of Pharmacovigilance, 2019, 16(2): 110-114.

References

[1] 魏亚宁, 臧爱民, 杨华, 等. 奥沙利铂联合氟尿嘧啶化疗后出现致死性脑白质病1例并文献复[J]. 医学研究与教育, 2015, 32(2):106-108.
[2] 李瑞林, 邓长英. 奥沙利铂引起的溶血性贫血[J]. 国外医学药学分册, 2000, 27(4) :254-255.
[3] 赵阳, 安欣, 向晓娟, 等. 中国结直肠癌患者奥沙利铂过敏反应的临床特征[J]. 癌症, 2010, 29(1):102-105.
[4] 赵波, 钟华戈, 高枫, 等. 广西3720例结直肠癌临床流行病学分析[J]. 广东医学, 2013, 34(14):2239-2242.
[5] 王继荣, 李娟, 王娟,等. FOLFOX4与XELOX治疗晚期大肠癌临床对比观察[J]. 中国医药导报, 2012, 9(36):98-100.
[6] Markman M.Toxicities of the platinum antineoplastic agents[J]. Expert Op in Drug Saf,2003, 2(6):597-607.
[7] 贺秀丽,方英立. 奥沙利铂致过敏反应分析[J]. 中国医院药学杂志, 2010, 30(1):92-93.
[8] 李特, 宋秋艳. 奥沙利铂致过敏反应1例[J].中国实用医药, 2014, 9(3) :195-196.
[9] Thomas R R, Quinn M G, Schuler B, et al.Hypersensi-tivity and idiosyncratic reactions to oxaliplatin[J]. Cancer, 2003, 97(7):2301-2307.
[10] 蔡强, 王秀问, 方英立, 等. 奥沙利铂过敏反应临床资料分析[J]. 山东大学学报 (医学版) , 2011,49(12):149-152.
[11] 陈小兵, 吕慧芳, 陈贝贝, 等. 奥沙利铂神经毒性机制及防治研究进展[J]. 中国医药科学, 2012, 2(3):38-40.
[12] 陈曙东, 周永刚, 吴冬妮. 79例奥沙利铂相关不良反应分析[J]. 今日药学, 2017,27(1):45-47.
[13] 李倩. 奥沙利铂的神经毒性和防治进展[J]. 上海交通大学学报(医学版), 2006, 26(4):430-433.
[14] 张景涛,林丽珠. 奥沙利铂致急性血小板减1例[J]. 中国肿瘤临床与康复, 2014, 1(21):123-124.
[15] Maindrault-Goebel F, Andre T, Tournigand C, et al.Allergic-type reactions to oxaliplatin:retrospective analysis of 42 patients[J]. Eur J Cancer, 2005, 41(15):2262-2267.
[16] 魏雪, 潘莹, 刘韬, 等. 奥沙利铂注射液致尿失禁 1 例[J]. 中国药物警戒, 2010, 7(11):696.
[17] 甘克刚, 冯龙. 草酸铂联合 CF+5-Fu 化疗致病态窦房结综合症一例[J]. 实用临床医学, 2008, 8(3):44-45.
[18] Pontes L B, Armentano D P, Soares A, et al.Fatal pneumonitis induced by oxaliplatin: Description of three cases[J]. Case RepOncol, 2012, 5(1):104-109.