Abstract: Objective A data analysis of the adverse drug reactions (ADRs) induced by iohexol injection was conducted to understand the characteristics of The ADRs and provide technical support for the clinical safe use of the drug. Methods A total of 890 ADR reports collected by the Beijing Center for ADR Monitoring on iohexol injection inducing ADRs between 2003 and 2016 were sorted out and analyzed. Results ADRs, being on the increase year by year, mainly occur in people over the age of 40. Systems and organs affected by ADRs were mainly observed to be skin and appendages disorders, gastrointestinal disorders, and systematic disorders. A total of 60 cases of severe ADRs, including 7 cases of death, occurred, where anaphylactic shock, anaphylactic reaction, renal impairment, aphasia were the typical manifestations. Conclusion It is important that sufficient attention be paid to ADRs caused by iohexlo injection, with special focus on improving the ability to identify and treat severe ADRs.

Key words: iohexol injection, adverse drug reaction, analysis, rational use of drug