Abstract: Objective To study the safety of the different components of Flos Magnolia Nose Drop in guinea pig and to provide experimental data for safe use in clinical. Methods The acute toxicity experiment: The different components of Flos Magnolia Nose Drop were administrated to guinea pig and the acute toxic symptoms were observed. The mucosal irritation experiment: The different components of Flos Magnolia Nose Drop were administrated to guinea pig' nasal cavity and the degree of nasal irritation was observed. Results We did not find the chronic toxicity and the mucosal irritation to guinea pig' nasal cavity after given Flos Magnolia Nose Drop for7 days. Conclusion The acute toxicity test and the mucosal irritation test showed that the Flos Magnolia Nose Drop was safe.

Key words: different components of Flos Magnolia Nose Drop, acute toxicity experiment, mucosal irritation experiment, safety