Abstract: Objective The antiallergenic mechanisms of effective parts from Flos Magnoliae were studied, so as to provide references and research ideas for antiallergenic drugs and innovative drugs. Methods The effect of sensitized rat peritoneal mast cells(PMC) degranulation and the release of histamine about Flos Magnoliae effective parts of the freeze-dried powder of serum drug were observed through the patterns and fluorescence, the antiallergenic effects of Flos Magnoliaewas researched and the antiallergenic mechanisms was studied. Results The PMC degranulation and the release of histamine were significantly inhibited after given the preparation of freeze -dried powder of serum drug 15 and 60min, and there are some limitations relations. The antiallergenic mechanisms of Flos Magnoliae may be related to the mast cell membrane stability, inhibiting their degranulation and the release of allergic media. Conclusion The effective parts of Flos Magnoliae has an significant effect, and there are some relations about Flos Magnoliae effective antiallergenic parts and the release of allergic PMC medium-the histamine.

Key words: Flos Magnoliae, antiallergy, mechanisms