Abstract: Objective Through analysing 63 ADR cases of the capecitabine platinum joint Fluorouracil/leucovor in treatment of colorectal cancer, to explore the rules and causes of adverse reactions, provide a reference for clinical rational use of drugs. Methods Analyzed 63 ADR cases caused by capecitabine platinum joint fluorouracil/leucovor in treatment of colorectal cancer in terms of gender, age, drug dose, organ or system involved and clinical manifestation, which were searched from 2007～2012 at the Affiliated Hospital of Qinghai University. Results Patients at the age of forty to sixty were with the highest incidence of ADR,a total of 39 cases, accounting for 61.90% . The most common clinical manifestations of ADR was nervous system damage(44.44%), followed by the digestive system(29.63%) and blood system (17.78%) damage. Conclusion The occurrence of ADR caused by FOLFOX scheme colorectal cancer treatment was related to drug factors, and age distribution characteristics accorded with the adaptation crowd. The medical professionals should raise the awareness of reporting ADR induced by FOLFOX scheme in the treatment of malignant tumor. It needs to analyze the characteristics of the ADR occurrence to ensure the clinical drug use safety.

Key words: capecitabine platinum joint fluorouracil/leucovor, colorectal cancer, adverse drug reaction(ADR)