Abstract: Objective To analyze the rationality of clinical use of Reduning injection and consequent adverse drug reactions in our hospital in order to provide reference for the rational use of Reduning injection in children. Methods Data on all the cases of children who received Reduning injection in our hospital between December 2017 and November 2018 was retrieved, and a total of 1073 cases were selected. Adverse drug reactions were analyzed using Pareto charts and fishbone diagrams. Results Improper medication was found in 532 (49.58 %) of the 1073 cases who used Reduning injection. of which off-labeled use (56.58 %) and over-course of treatment (24.25 %) were the leading factors. The secondary factor was undifferentiated medication(12.22 %). ADR occurred in 22 of the 1 073 cases, accounting for 2.05 % and related to off-labeled use, beyond-the-course medication , intravenous drug concentration and drip rate, and patients themselves. 59.09 % of the adverse reactions were caused by off-labeled use and 31.82 % by beyond-the-course treatment. Conclusion There is something irrational about the way Reduning injection is used in our hospital. The hospital can strengthen the real-time monitoring and intervention of the use of TCM injections with the risk factors in mind.

Key words: Reduning injection, pareto chart, fishbone diagram, rational use of medicine, adverse drug reaction（ADR）