Abstract: Objective To study the features of adverse drug reaction(ADR) in cardiovascular system induced by -lactam antibiotics through literature analysis and provide reference for clinical rational use of β-lactam antibiotics. Methods To collect literatures from 1987 to 2012 reported in China National Knowledge Infrastructure (CNKI) with" β-lactam antibiotics"、"penicillin"、" cef -/ceph -" "ADR" as key words, and to analyze statistically the 65 ADR cases, involved in 43 articles of β-lactam antibiotics in cardiovascular system. Results Totally there were 16 varieties involved. Penicillin was most frequently reported. Cefazolin and cefradine were the second. Arrhythmia was the most common manifestation of cardiac toxicity(73.85% ), followed by acute heart failure (23.08% ). Most ADR appeared as fast -type, especially occurred during the first 10 minutes (53.85% ). Conclusion We should pay more attention to the ADR of β-lactam antibiotics in cardiovascular system. It needs to observe closely during application, in order to detect earlier and deal correctly.

Key words: adverse drug reaction(ADR), β-lactam, cardiovascular system