Abstract: Objective To study the general pattern and characteristics of adverse drug reactions induced by vidarabine monophosphate injection to provide references for clinical rational use of drug. Methods 409 cases of ADR related to the vidarabine monophosphate injection from January 2004 to July 2014 in Henan province were analyzed using retrospective study method.The drug instructions of two domestic pharmaceutical enterprises were compared. Results Among 409 reports, children aged 14 years old accounted for 88.02%, but there was no children informations in the drug instructions. 215 cases of drug combination accounted for 52.57%, and the combination species were focused on antibiotics(68.38%). The main ADR was damage to skin and its attachment(56.55%), and the major clinical manifestations were skin rashs(44.40%), itching(5.69%), etc, and there was no warning of these in the drug instructions. Conclusion It's important to pay attention to the ADR caused by vidarabine monophosphate injection, and perfect drug instuctions, in order to improve rational use of medicines in clinic, ensure clinical medication safety.

Key words: vidarabine monophosphate injection, adverse drug reaction/event, analysis