Abstract: Objection To explore the characters of the adverse reactions/events about cardiovascular system caused by azithromycin. Methods 1 321 reports of the adverse reactions/events about cardiovascular system caused by azithromycin were analyzed via retrospective study. Results Azithromycin may lead to adverse reactions such as palpitations, chest tightness, tachycardia,etc. The risk of intravenous delivery was dominant. The adverse reactions about cardiovascular system occurred within 30 min. Conclusion It is necessary to reevaluate the risk of azithromycin for specific populations of safety and adverse effects about cardiovascular system. On this basis, modify the drug instructions and make the necessary warning for the safety of its intravenous administration.

Key words: azithromycin, cardiovascular system, adverse reaction/event