Abstract: Objective To explore the situation and rules of adverse drug reactions of Gd -DTPA injection, in order to provide reference for the rational use of drugs in clinic. Methods We collected the literatures related to the adverse reactions of Gd -DTPA injection in WANFANG Database from 2002 to 2012, and conducteda statistical analysis. Results The Results showed that the ratio of male to female was 1:1.2. Most adverse reactions occurred whthin 30 minutes after medication. There were 59 cases(44%) of non-allergic reactions, 47 cases(35%) of mild allergic reactions, 10 cases(8 % ) of moderate allergic reactions ,18 cases( 13% ) of severe allergic reactions ,of which 6 cases ( 4% ) died. Conclusion In spite of Gd-DTPA injection with low incidence of adverse reaction, it can still cause severe allergic reactions and even death. Pharmacists should strengthen the monitoring because of its use in imaging diagnosis without clinical care.

Key words: Gd-DTPA injection, adverse drug reaction, literature analysis