Abstract: Objective To optimize formula of prulifloxacin dispersible tablets. Methods Tablet weight variation, disintegrate time and dissolution rate were used as the quality index, excipients were progressively adjusted to form optimizational formula for prulifloxacin dispersible tablets. Results MCC as an excipient, PVP as an adhesive, L-HPC as a disintegrant and talc powder as a lubricant of the dispersible tablet formula. The dissolution rate of the dispersible tablet was faster than that of the conventional tablet. Conclusion The prepared prulifloxacin indispersible tablet is reasonable in formula, feasible in scale up to production and it meets the quality standards.

Key words: prulifloxacin, dispersible tablet, formula