Abstract: Objective To evaluate the clinical efficacy of clinical pharmacists’ involvement in the design of a total nutrition admixture (TNA) formulary to provide individualized dosing regimens for patients. Methods The clinical data of patients with digestive disorders treated with parenteral nutrition support between January 1, 2020 and December 15, 2021 was retrospectively studied. There were 49 cases in the individualized total nutrition admixture infusion group (individualized group) in which clinical pharmacists participated and another 56 cases in the single bottle infusion of nutritional drugs group (single bottle group). Such data as the nutritional indexes, liver and kidney function indicators, complications, adverse reactions, and hospital stay were collected. Results The levels of prealbumin, retinol-binding protein. C-reactive protein and creatinine in the individualized group changed significantly after treatment, so were the levels of prealbumin and creatinine in the single bottle group (P<0.05). Levels of urea and pre-albumin were significantly different in the two groups after treatment. Prealbumin and retinol binding protein decreased in the single bottle group after treatment, but increased in the individualized group. C-reactive protein decreased in both groups after treatment, especially in the individualized group (P<0.05), but there was no statistically significant difference in other indexes. The rate of complications was 6.12% in the individualized group, significantly lower than 19.6% in the single bottle group (P<0.05). There was significant difference between the two groups in the duration of parenteral nutrition support [(14.66±7.15) d vs (10.41±8.22)d] (P<0.05), but not in the length of hospital stay. No related adverse reactions were reported in either group. Conclusion The individualized group has better efficacy than in the single bottle group, which can help clinicians better understand the benefits pharmacists’ involvement in parenteral nutrition therapy. The individualized parenteral nutrition support therapy helps improve clinical outcomes.

Key words: clinical pharmacist, parenteral nutrition, individualized formulary, efficacy evaluation