Abstract: Objective In order to further clarify the significance and actively explore the work mechanism of adverse drug reaction monitoring. Methods On the basis of work significance and effectiveness of adverse drug reaction monitoring, analyze the current problems existing in the adverse drug reaction monitoring, then pertinently put forward job security mechanism; Results &Conclusion The establishment and implementation of personnel, functions, funds, rewards punishment, participation, coordination, expert consultation, emergency disposal and other work mechanism, will contribute stimulative effect to the current adverse drug reaction monitoring work.

Key words: adverse drug reaction(ADR), adverse drug reaction monitoring and reevaluation, mechanism