Research Progress in Chemical Composition, Pharmacological Effect, Chinese Materia Medica Processing and Toxicological Properties of BUPLEURI RADIX

doi:10.19803/j.1672-8629.20240996

Abstract

Abstract: Objective To summarize the latest progress in research on the chemical composition, pharmacological effects, Chinese materia medica processing and toxicological properties of BUPLEURI RADIX so as to provide a reference for applications and development of this drug. Methods Based on literature review and data integration, the clinical applications, chemical composition, pharmacological effects, processing methods, and toxicological properties of BUPLEURI RADIX were analyzed. Results Different processing methods yielded varying forms, such as raw BUPLEURI RADIX, vinegar-processed BUPLEURI RADIX, wine-processed BUPLEURI RADIX, turtle blood-processed BUPLEURI RADIX and honey-fried BUPLEURI RADIX, each with distinct therapeutic properties. Raw and vinegar forms were predominantly used in clinical settings. Pharmacological studies demonstrated its antipyretic, analgesic, anti-inflammatory, immunoregulatory, antidepressant, hepatoprotective, and antitumor activities. Despite its clinical efficacy, improper use could lead to pulmonary and hepatic toxicity, necessitating careful dosage and duration management. Conclusion In the future, the changes in the chemical composition structure caused by the processing of BUPLEURI RADIX, a detailed comparison of the pharmacological effects and material basis of various processed decoction pieces, and the toxicological research on processed products of BUPLEURI RADIX will be good options for research. Further research can be conducted on the role of Bupleurum chinense in heart protection, kidney protection, relief of gastric ulcers, anti-allergy treatment, and alleviation of Alzheimer’s disease.

Key words: BUPLEURI RADIX, Chemical Composition, Pharmacological Effects, Chinese Materia Medica Processing, Toxicological Properties, Clinical Application

CLC Number:

R994.11

NIU Yuanfei, LIU Meiting, SHI Yujing, RONG Wenshuang, MA Lina, ZHENG Changhui, FU Yao, WANG Lianmei, CAO Junling. Research Progress in Chemical Composition, Pharmacological Effect, Chinese Materia Medica Processing and Toxicological Properties of BUPLEURI RADIX[J]. Chinese Journal of Pharmacovigilance, 2025, 22(9): 1073-1080.

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