Abstract: Objective To analyze the patterns and clinical characteristics of adverse drug reactions (ADR) induced by intravenous drip of antibacterial drugs so as to provide references for safe clinical medications. Methods Reports of ADR induced by antibacterials for intravenous drip submitted by our hospital to the National Adverse Drug Reaction Monitoring Center in 2016-2024 were collected and analyzed in terms of patients' gender and age, primary diseases, types of drugs involved in ADR, time of onset, systems and organs involved, clinical manifestations, outcomes and distribution of ADR. Results Among the 887 cases of ADR, 257 were new and mild ADR, 32 were new and severe ones, and 57 were severe ones. Among the patients involved in these ADR, 52.31% were male and 47.69% were female. The percentage of patients ages 60 and older was the highest (40.47%). Totally 40 types of antibiotics of 15 classes were involved, and the top three categories were cephalosporins (28.97%), quinolones (25.59%) and β-lactamase inhibitor combinations (20.52%) respectively. The top three drugs were ceftriaxone (17.59%), piperacillin-tazobactam (15.67%) and levofloxacin (14.54%). ADR mostly occurred within 30 minutes of administration (42.05%), and involved the skin and its accessories (62.31%), the nervous system (9.20%) and digestive system (9.02%). Most of these ADR were cured or improved after symptomatic treatment. Conclusion The clinical manifestations of adverse reactions caused by antibacterial drugs for intravenous drip are diverse, and what deserves more attention is severe ADR, including anaphylactic shock, allergy-like reactions, epileptic seizures, thrombocytopenia, coagulation disorders and abnormal liver function. New ADR are difficult to predict. Clinicians should devote more effort to monitoring of ADR, especially those among special populations and due to high-risk drugs so as to reduce the incidence of ADR and ensure safe medications.

Key words: Antibacterial Drugs, Cephalosporins, Quinolones, β-Lactamase, Intravenous Drip, Skin and Its Accessories, Nervous System, Digestive System, Adverse Drug Reaction