Research Progress in Biological Activity and Mechanisms of Pachymic Acid

doi:10.19803/j.1672-8629.20240121

Abstract

Abstract: Objective To advance the understanding of pachymic acid in order to explore its potentials and to promote its clinical applications. Methods A systematic literature review was conducted to retrieve studies on pachymic acid. The biological activities and mechanisms of action were summarized while future developments were predicted. Results Pachymic acid could be extracted from various natural sources and demonstrated potentials in the treatment of multiple diseases. It could possibly exert antitumor and anti-ischemic/reperfusion injury effects by modulating the cell cycle, apoptosis-related factors, and several signaling pathways, including NF-κB, Shh/Gli1 and JAK2/STAT3/SOCS3. In addition, pachymic acid garnered attention for its role in inflammation regulation and could potentially impact such conditions as pneumonia, asthma, radiation-induced lung injury, colitis, cystitis, and osteoarthritis. Conclusion Pachymic acid exhibits significant biological activity, revealing its potential applicability in the treatment of various diseases, including tumors, ischemic injury and inflammation.

Key words: Pachymic Acid, Biological Activity, Mechanisms, Tumors, Ischemic Injury, Inflammation, Research Progress

CLC Number:

R961

LIU Ming, ZHENG Li, ZHANG Weina, SUN Xuelin, TIAN Jinhui, ZHAO Yan. Research Progress in Biological Activity and Mechanisms of Pachymic Acid[J]. Chinese Journal of Pharmacovigilance, 2025, 22(7): 826-830.

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https://zgywjj.magtechjournal.com/EN/Y2025/V22/I7/826

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