Abstract: Objective To study the characteristics of thrombocytopenia induced by cefoperazone sulbactam sodium, and to provide a reference for safe clinical use and management of adverse drug reactions. Methods One case of thrombocytopenia caused by cefoperazone sulbactam sodium for injection was studied. The adverse reactions and pathogenesis of thrombocytopenia caused by cefoperazone sulbactam sodium were analyzed via correlation evaluation and literature review before ways of prevention and treatment were recommended. Results After the drug instructions and literature were reviewed, and the time of administration was analyzed, other combination drugs were excluded. Cefoperazone sulbactam sodium was considered to have caused the adverse reactions. After drug withdrawal and supportive treatment, the patient’s platelets gradually returned to normal. Conclusion It is recommended that clinicians be alert to the risk of thrombocytopenia associated with antibiotics such as cefoperazone sulbactam, and monitor platelets during medication in high-risk groups such as the elderly, severe patients, those under a long course of medication, and those with hepatic and renal insufficiency so as to ensure the safety of patients.

Key words: Cefoperazone Sulbactam Sodium, Thrombocytopenia, Adverse Drug Reaction, Antibiotics, Rational Drug Use