Abstract: Objective To analyze such adverse reactions as acute severe liver injury caused by glucocorticoids and provide a reference for clinical drug safety. Methods One case of acute severe liver injury that occurred after the administration of high-dose dexamethasone sodium phosphate injection in a patient with primary immune thrombocytopenia was analyzed in combination with related literature. Results Based on the patient’s clinical manifestations, results of laboratory tests, and the timing of drug administration, the patient’s acute severe liver injury was considered an adverse reaction caused by high-dose dexamethasone sodium phosphate injection. Conclusion Close monitoring of adverse reactions is critical when glucocorticoids are used clinically, especially at a high dose, and clinicians should be alert to such adverse reactions as liver injury.

Key words: Dexamethasone Sodium Phosphate, Injection, Glucocorticoid, Dose, Adverse Drug Reaction, Liver Injury